Emerging ecotone

Along with the development of society and economy, waste landscape becomes an inevitable result of urban involvement where technological innovation plays a very important role. Computer science, as the most important technology in the 21st century, also affects the physical spaces by enlarging our social distance. People prefer to contact physically less with others unless necessary, causing shrinkage of our community spaces. Abandoned commercial space, which has lost its social function, is one of the typical effects derived from both economic evolution and community shrinking. In fact, Josh Sanburn (2017) in TIME mentioned “by 2022, analysts estimate that 1 out of every 4 malls in the U.S. could be out of business1,” which leaves amounts of empty buildings and wasted landscapes in urban and suburban areas. According to an article in The New York Times, dead malls are malls that have their glorious history but at least 40% of retail space is not used anymore2. They reflect that people’s attitude toward shared space has changed and demonstrate the limitation of physical space serve only one function under the context that is always changing. So, it’s our responsibility as landscape architects to explore possible ways of fitting multiple functions in limited spaces in order to enable a sustainable social and ecological community. Rhode Island Mall in Warwick, RI, as one of the oldest big box malls in New England, was the start of a long boom in building retail space of all kinds. But nowadays, this place reflects the changing of economy and switching of people’s shopping habits nationwide. In addition, even though the building is surrounded by abundant community types of neighborhood, they are kept isolated by highways and a under utilized river, Pawtuxet River. So the isolation due to physical and sociological aspects makes the mall area a “lonely island”. In this thesis, I treat the dying mall as a catalyst vessel of cultural activities to reunite communities, and also reveal the river as a thread to connect the surrounding communities for revitalizing the whole area. In terms of that, I take the design of Rhode Island Mall as a model to discuss how we create a “social ecotone” for reshaping the under valued space to valuable area in both social and ecological way

High-aspect-ratio dielectric pillar with nanocavity backed by metal substrate in the infrared range

We investigated absorption and field enhancements of shallow nanocavities on top of high-aspect-ratio dielectric pillars in the infrared range. The structure includes a high-aspect-ratio nanopillar array of high refractive index, with nano-cavities on top of the pillars, and a metal plane at the bottom. The enhancement factor of electric field intensity reaches 3180 in the nanocavities and peak absorption reaches 99% . We also investigated the finite-size effect of the presented structure to simulate real experiments. Due to its narrow absorption bandwidth 3.5 nm, it can work as a refractive index sensor with sensitivity 297.5 nm/RIU and figure of merit 85. This paves the way to directly control light field at the nanoscales in the infrared light range. The investigated nanostructure will find applications in multifunctional photonics devices such as chips for culturing cells, refractive index sensors, biosensors of single molecule detection and nonlinear sensors

RET rearrangement-positive pancreatic cancer has remarkable response to pralsetinib: a case report

Patients with metastatic pancreatic cancer have limited treatment options and a dismal prognosis. While RET fusion is rare (0.6%) in pancreatic cancer, the efficacy of RET-targeted treatment in patients with TRIM33-RET fusion has not been previously reported. Herein, we presented a case of a 68-year-old man with pancreatic cancer harboring TRIM33-RET fusion who responded remarkably to pralsetinib despite being intolerant to chemotherapy. To our knowledge, this is the first report on the clinical value of a single TRIM33-RET fusion in pancreatic cancer, which may benefit from the targeted therapy

Perfluorocarbon nanodrug induced oxygen self-enriching sonodynamic therapy improves cancer immunotherapy after insufficient radiofrequency ablation

Residual lesions and undetectable metastasis after insufficient radiofrequency ablation (iRFA) are associated with earlier new metastases and poor survival in cancer patients, for induced aggressive tumor phenotype and immunosuppression. Programmed cell death protein 1(PD-1) blockade has been reported to enhance the radiofrequency ablation-elicited antitumor immunity, but its ability to eliminate incompletely ablated residual lesions has been questioned. Here, we report a combined treatment modality post iRFA based on integrating an oxygen self-enriching nanodrug PFH-Ce6 liposome@O2 nanodroplets (PCL@O2)-augmented noninvasive sonodynamic therapy (SDT) with PD-1 blockade. PCL@O2 containing Ce6 as the sonosensitizer and PFH as O2 reservoir, was synthesized as an augmented SDT nanoplatform and showed increased ROS generation to raise effective apoptosis of tumor cells, which also exposed more calreticulin to induce stronger immunogenic cell death (ICD). Combining with PD-1 blockade post iRFA, this optimized SDT induced a better anti-tumor response in MC38 tumor bearing mouse model, which not only arrested residual primary tumor progression, but also inhibited the growth of distant tumor, therefore prolonging the survival. Profiling of immune populations within the tumor draining lymph nodes and tumors further revealed that combination therapy effectively induced ICD, and promoted the maturation of dendritic cells, tumor infiltration of T cells, as well as activation of cytotoxic T lymphocytes. While iRFA alone could result in an increase of regulatory T cells (Tregs) in the residual tumors, SDT plus PD-1 blockade post iRFA reduced the number of Tregs in both primary and distant tumors. Moreover, the combined treatment could significantly initiate long-term immune memory, manifesting as elevated levels of CD8+ and CD4+ central memory cells. Therefore, this study establishes the preclinical proof of concept to apply oxygen self-enriching SDT to augment cancer immunotherapy after iRFA

Intelligent Computing: The Latest Advances, Challenges and Future

Computing is a critical driving force in the development of human civilization. In recent years, we have witnessed the emergence of intelligent computing, a new computing paradigm that is reshaping traditional computing and promoting digital revolution in the era of big data, artificial intelligence and internet-of-things with new computing theories, architectures, methods, systems, and applications. Intelligent computing has greatly broadened the scope of computing, extending it from traditional computing on data to increasingly diverse computing paradigms such as perceptual intelligence, cognitive intelligence, autonomous intelligence, and human-computer fusion intelligence. Intelligence and computing have undergone paths of different evolution and development for a long time but have become increasingly intertwined in recent years: intelligent computing is not only intelligence-oriented but also intelligence-driven. Such cross-fertilization has prompted the emergence and rapid advancement of intelligent computing. Intelligent computing is still in its infancy and an abundance of innovations in the theories, systems, and applications of intelligent computing are expected to occur soon. We present the first comprehensive survey of literature on intelligent computing, covering its theory fundamentals, the technological fusion of intelligence and computing, important applications, challenges, and future perspectives. We believe that this survey is highly timely and will provide a comprehensive reference and cast valuable insights into intelligent computing for academic and industrial researchers and practitioners

Intelligent computing : the latest advances, challenges and future

Computing is a critical driving force in the development of human civilization. In recent years, we have witnessed the emergence of intelligent computing, a new computing paradigm that is reshaping traditional computing and promoting digital revolution in the era of big data, artificial intelligence and internet-of-things with new computing theories, architectures, methods, systems, and applications. Intelligent computing has greatly broadened the scope of computing, extending it from traditional computing on data to increasingly diverse computing paradigms such as perceptual intelligence, cognitive intelligence, autonomous intelligence, and human computer fusion intelligence. Intelligence and computing have undergone paths of different evolution and development for a long time but have become increasingly intertwined in recent years: intelligent computing is not only intelligence-oriented but also intelligence-driven. Such cross-fertilization has prompted the emergence and rapid advancement of intelligent computing

Diffusion through a polycrystalline thin film

Analytical solutions to Fick's second law of diffusion have been simultaneously derived without the restrictions of parabolic profiles along the x-axis in grain boundaries and expressed in a series for both grain interior and grain boundary diffusing through a polycrystalline thin film. The analysis takes segregation of diffusion species at grain boundaries into account. The analytic solutions lead to the concentration profiles in the grain interior and in the grain boundary, to the average-integrated amount of diffusion species at the exit surface, and to the time lag, which can be technologically used for depth profile studies and kinetic accumulation measurements

Solute Concentrations and Strains in Nanograined Materials

Taking advantage of both the Gibbs and McLean adsorption isotherms, we develop a Gibbs-approach-based adsorption isotherm for grain boundary (GB) segregation in nanograined (ng) polycrystals. An excess GB thickness is introduced to describe the excess of GB atomic volume in comparison with the atomic volume in lattice. The GB bulk modulus is determined with the excess GB thickness and a universal function. The newly developed adsorption isotherm is able to analyze simultaneously stresses, concentrations and their coupling behaviors in grains and GBs. Numerical calculations and plots are conducted to illustrate the theoretical analysis. The results show that the apparent solute concentration could be greatly enhanced in ng materials, due to a large grain boundary volume fraction and a considerable increase in the lattice concentration that is, in turn, boosted by the concentration-induced stresses. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved

Effect of electrostatic tractions on the fracture behavior of a dielectric material under mechanical and/or electric loading

The effect of electrostatic tractions on the fracture behavior of a dielectric material under mechanical and/or electric loading is analyzed, by studying a pre-cracked parallel-plate capacitor, and illustrated by plots. The results indicate that electrostatic tractions on the electrodes compress the material in front of the crack tip, while electrostatic tractions on the crack faces have the tendency to close the crack and stretch the material behind the crack tip. Mechanical load is the driving force to propagate the crack, while applied electric field retards crack propagation due to the electrostatic tractions. As a direct consequence, the fracture criterion is composed of two parts: the energy release rate must exceed a critical value and the mechanical load must be higher than the critical value for crack opening